Polyadenylation of ribosomal RNA by Candida albicans also involves the small subunit.

ABSTRACT:

Background

Candida albicans is a polymorphic fungus causing serious infections in immunocompromised patients. It is capable of shifting from yeast to germinating forms such as hypha and pseudohypha in response to a variety of signals, including mammalian serum. We have previously shown that some of the large 25S components of ribosomal RNA in Candida albicans get polyadenylated, and this process is transiently intensified shortly after serum exposure just prior to the appearance of germination changes.

Results

We now present data that this process also involves the small 18S subunit of ribosomal RNA in this organism. Unlike the large 25S subunit, polyadenylation sites near the 3' end are more variable and no polyadenylation was found at the reported maturation site of 18S. S

SUBMITTER: Fleischmann J 

PROVIDER: S-EPMC522811 | biostudies-literature | 2004 Oct

REPOSITORIES: biostudies-literature