Sustained kidney biochemical derangement in treated experimental diabetes: a clue to metabolic memory.

ABSTRACT: The occurrence of biochemical alterations that last for a long period of time in diabetic individuals even after adequate handling of glycemia is an intriguing phenomenon named metabolic memory. In this study, we show that a kidney pathway is gradually altered during the course of diabetes and remains persistently changed after late glycemic control in streptozotocin-induced diabetic rats. This pathway comprises an early decline of uric acid clearance and pAMPK expression followed by fumarate accumulation, increased TGF-β expression, reduced PGC-1α expression, and downregulation of methylation and hydroxymethylation of mitochondrial DNA. The sustained decrease of uric acid clearance in treated diabetes may support the prolonged kidney biochemical alterations observed after tight glycemic c

SUBMITTER: de Oliveira AA 

PROVIDER: S-EPMC5228190 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature