Dexmedetomidine prevent postoperative nausea and vomiting on patients during general anesthesia: A PRISMA-compliant meta analysis of randomized controlled trials.

ABSTRACT:

Background

Postoperative nausea and vomiting (PONV) is a frequent complication in postoperative period. The aim of this article was to evaluate the effect of dexmedetomidine on PONV.

Method

RevMan 5.3 software was applied for performing statistic analysis. Twenty-four trials with 2046 patients were included.

Results

The PONV of the dexmedetomidine group was significantly lower compared with the placebo group (0.56, 95% CI: 0.46, 0.69). Subgroup analysis further confirmed the effect of dexmedetomidine (irrespective of administration mode) (P < 0.00001). Perioperative fentanyl consumption in dexmedetomidine group were also reduced significantly (P < 0.00001). Whereas, side effects such as bradycardia, hypotension increased in dexmedetomidine group (especially in loading

SUBMITTER: Jin S 

PROVIDER: S-EPMC5228682 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature