A first-draft human protein-interaction map.

ABSTRACT:

Background

Protein-interaction maps are powerful tools for suggesting the cellular functions of genes. Although large-scale protein-interaction maps have been generated for several invertebrate species, projects of a similar scale have not yet been described for any mammal. Because many physical interactions are conserved between species, it should be possible to infer information about human protein interactions (and hence protein function) using model organism protein-interaction datasets.

Results

Here we describe a network of over 70,000 predicted physical interactions between around 6,200 human proteins generated using the data from lower eukaryotic protein-interaction maps. The physiological relevance of this network is supported by its ability to preferentially connect

SUBMITTER: Lehner B 

PROVIDER: S-EPMC522870 | biostudies-literature | 2004

REPOSITORIES: biostudies-literature