The Role of TOR1A Polymorphisms in Dystonia: A Systematic Review and Meta-Analysis.

ABSTRACT:

Importance

A number of genetic loci were found to be associated with dystonia. Quite a few studies have been contacted to examine possible contribution of TOR1A variants to the risk of dystonia, but their results remain conflicting. The aim of the present study was to systematically evaluate the effect of TOR1A gene SNPs on dystonia and its phenotypic subtypes regarding the body distribution.

Methods

We performed a systematic review of Pubmed database to identify all available studies that reported genotype frequencies of TOR1A SNPs in dystonia. In total 16 studies were included in the quantitative analysis. Odds ratios (ORs) were calculated in each study to estimate the influence of TOR1A SNPs genotypes on the risk of dystonia. The fixed-effects model and the random effects

SUBMITTER: Siokas V 

PROVIDER: S-EPMC5231385 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature