Frequency of Propionibacterium acnes Infection in Prostate Glands with Negative Biopsy Results Is an Independent Risk Factor for Prostate Cancer in Patients with Increased Serum PSA Titers.

ABSTRACT:

Background

Propionibacterium acnes has recently been implicated as a cause of chronic prostatitis and this commensal bacterium may be linked to prostate carcinogenesis. The occurrence of intracellular P. acnes infection in prostate glands and the higher frequency of P. acnes-positive glands in radical prostatectomy specimens from patients with prostate cancer (PCa) than in those from patients without PCa led us to examine whether the P. acnes-positive gland frequency can be used to assess the risk for PCa in patients whose first prostate biopsy, performed due to an increased prostate-specific antigen (PSA) titer, was negative.

Methods

We retrospectively collected the first and last prostate biopsy samples from 44 patients that were diagnosed PCa within 4 years after the firs

SUBMITTER: Kakegawa T 

PROVIDER: S-EPMC5231393 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature