Ontology highlight
ABSTRACT:
SUBMITTER: Tenente IM
PROVIDER: S-EPMC5231408 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
eLife 20170112
Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the field has been that expression of these factors likely reflects the target cell of transformation rather than being required for continued tumor growth. Here, we used a transgenic zebrafish model to show that Myf5 is sufficient to confer tumor-propagating potential to RMS cells and caused tumors to initiate earlier and have highe ...[more]