Cell surface delivery of the measles virus nucleoprotein: a viral strategy to induce immunosuppression.

ABSTRACT: Although only a few blood cells are infected during measles, this infectious disease is followed by acute immunosuppression, associated with high infant mortality. Measles virus nucleoprotein has been suggested to contribute to virus-induced inhibition of the immune response. However, it has been difficult to understand how this cytosolic viral protein could leave an infected cell and then perturb the immune response. Here we demonstrate that intracellularly synthesized nucleoprotein enters the late endocytic compartment, where it recruits its cellular ligand, the Fcgamma receptor. Nucleoprotein is then expressed at the surfaces of infected leukocytes associated with the Fcgamma receptor and is secreted into the extracellular compartment, allowing its interaction with uninfected cells. Fin

SUBMITTER: Marie JC 

PROVIDER: S-EPMC523264 | biostudies-literature | 2004 Nov

REPOSITORIES: biostudies-literature