Mannosylated poly(beta-amino esters) for targeted antigen presenting cell immune modulation.

ABSTRACT: Given the rise of antibiotic resistance and other difficult-to-treat diseases, genetic vaccination is a promising preventative approach that can be tailored and scaled according to the vector chosen for gene delivery. However, most vectors currently utilized rely on ubiquitous delivery mechanisms that ineffectively target important immune effectors such as antigen presenting cells (APCs). As such, APC targeting allows the option for tuning the direction (humoral vs cell-mediated) and strength of the resulting immune responses. In this work, we present the development and assessment of a library of mannosylated poly(beta-amino esters) (PBAEs) that represent a new class of easily synthesized APC-targeting cationic polymers. Polymeric characterization and assessment methodologies were designe

SUBMITTER: Jones CH 

PROVIDER: S-EPMC5233061 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature