Early age at start of antiretroviral therapy associated with better virologic control after initial suppression in HIV-infected infants.

ABSTRACT:

Objective

The report of the 'Mississippi baby' who was initiated on antiretroviral therapy (ART) within 30 h of birth and maintained viral suppression off ART for 27 months has increased interest in the timing of ART initiation early in life. We examined associations between age at ART initiation and virologic outcomes in five cohorts of HIV-infected infants and young children who initiated ART before 2 years of age in Johannesburg, South Africa.

Methods

We compared those who initiated ART early (<6 months of age) and those who started ART late (6-24 months of age). Two primary outcomes were examined: initial response to ART in three cohorts and later sustained virologic control after achieving suppression on ART in two cohorts.

Results

We did not observe consistent d

SUBMITTER: Shiau S 

PROVIDER: S-EPMC5233647 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature