Zika virus epidemic in Brazil. I. Fatal disease in adults: Clinical and laboratorial aspects.

ABSTRACT:

Background

Zika virus (ZIKV) was first detected in Brazil in May 2015 and the country experienced an explosive epidemic. However, recent studies indicate that the introduction of ZIKV occurred in late 2013. Cases of microcephaly and deaths associated with ZIKV infection were identified in Brazil in November, 2015.

Objectives

To determine the etiology of three fatal adult cases.

Study design

Here we report three fatal adult cases of ZIKV disease. ZIKV infection in these patients was confirmed by cells culture and/or real-time reverse transcriptase polymerase chain reaction (RT-qPCR) and by antigen detection using immunohistochemical assay. Samples of brain and other selected organs taken at autopsy from three patients were also analyzed by histopathological and immunoh

SUBMITTER: Azevedo RS 

PROVIDER: S-EPMC5233712 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature