Midlife Risk Factors for Impaired Physical and Cognitive Functioning at Older Ages: A Cohort Study.

ABSTRACT:

Background

Previous studies examined midlife risk factors separately for old-age impaired physical and cognitive functioning. We determined the overlap of risk factors for both domains of functioning within the same setting.

Methods

Biological and behavioral risk factors at age 50 years and cognitive and physical functioning were assessed 18 (SD = 5) years later in the Whitehall II study (N = 6,316). Impaired physical functioning was defined as ≥1 limitation on the activities of daily living scale. Impaired cognitive functioning was defined as Mini-Mental State Examination score <27. Two statistical analyses were employed: minimally adjusted analysis (for age, sex, and ethnicity) and mutually adjusted analysis (including all risk factors). Missing data on risk factors were i

SUBMITTER: Brunner EJ 

PROVIDER: S-EPMC5233910 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature