Sialic Acid-Responsive Polymeric Interface Material: From Molecular Recognition to Macroscopic Property Switching.

ABSTRACT: Biological systems that utilize multiple weak non-covalent interactions and hierarchical assemblies to achieve various bio-functions bring much inspiration for the design of artificial biomaterials. However, it remains a big challenge to correlate underlying biomolecule interactions with macroscopic level of materials, for example, recognizing such weak interaction, further transforming it into regulating material's macroscopic property and contributing to some new bio-applications. Here we designed a novel smart polymer based on polyacrylamide (PAM) grafted with lactose units (PAM-g-lactose_0.11), and reported carbohydrate-carbohydrate interaction (CCI)-promoted macroscopic properties switching on this smart polymer surface. Detailed investigations indicated that the binding of

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC5234036 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature