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A Simple Thermoplastic Substrate Containing Hierarchical Silica Lamellae for High-Molecular-Weight DNA Extraction.


ABSTRACT: An inexpensive, magnetic thermoplastic nanomaterial is developed utilizing a hierarchical layering of micro- and nanoscale silica lamellae to create a high-surface-area and low-shear substrate capable of capturing vast amounts of ultrahigh-molecular-weight DNA. Extraction is performed via a simple 45 min process and is capable of achieving binding capacities up to 1 000 000 times greater than silica microparticles.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5234087 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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A Simple Thermoplastic Substrate Containing Hierarchical Silica Lamellae for High-Molecular-Weight DNA Extraction.

Zhang Ye Y   Zhang Yi Y   Burke Jeffrey M JM   Gleitsman Kristin K   Friedrich Sarah M SM   Liu Kelvin J KJ   Wang Tza-Huei TH  

Advanced materials (Deerfield Beach, Fla.) 20161108 48


An inexpensive, magnetic thermoplastic nanomaterial is developed utilizing a hierarchical layering of micro- and nanoscale silica lamellae to create a high-surface-area and low-shear substrate capable of capturing vast amounts of ultrahigh-molecular-weight DNA. Extraction is performed via a simple 45 min process and is capable of achieving binding capacities up to 1 000 000 times greater than silica microparticles. ...[more]

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