Molecular triangulation: bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease.

ABSTRACT: A major challenge in human genetics is identifying the molecular basis of common heritable disorders. In contrast to rare single-gene diseases, multifactorial disorders are thought to arise from the combined effect of multiple gene variants, such that any single variant may have only a modest effect on disease susceptibility. We present a method to identify genes that may harbor a significant proportion of the genetic variation that predisposes individuals to a given multifactorial disorder. First, we perform an automated literature analysis that predicts physical interactions (edges) among candidate disease genes (seed nodes, selected on the basis of prior information) and other molecular entities. We derive models of molecular networks from this analysis and map the seed nodes to them. W

SUBMITTER: Krauthammer M 

PROVIDER: S-EPMC523448 | biostudies-literature | 2004 Oct

REPOSITORIES: biostudies-literature