Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections with Obesity.

ABSTRACT: Proteomic studies can offer information on hundreds to thousands of proteins and potentially provide researchers with a comprehensive understanding of signaling response during stress and disease. Large data sets, such as those obtained in high-dimensional proteomic studies, can be leveraged for pathway analysis to discover or describe the biological implications of clinical disease states. Obesity is a worldwide epidemic that is considered a risk factor for numerous other diseases. We performed analysis on plasma proteomic data from 3 separate sample sets of postmenopausal women to identify the pathways that are altered in subjects with a high body mass index (BMI) compared to normal BMI. We found many pathways consistently and significantly associated with inflammation dysregulated in pl

SUBMITTER: Garrison CB 

PROVIDER: S-EPMC5234688 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature