Striatofrontal Deafferentiation in MSA-P: Evaluation with [18F]FDG Brain PET.

ABSTRACT:

Background

Although cognitive impairment is not a consistent feature of multiple system atrophy (MSA), increasing evidence suggests that cognitive impairment is common in MSA with predominant parkinsonism (MSA-P). It is assumed that the cognitive impairment in MSA-P is caused by the striatal dysfunction and disruption of striatofrontal connections. The aim of this study was to evaluate the relationship between regional glucose metabolism in the frontal cortex and striatum in patients with MSA-P using [18F]FDG brain PET.

Methods

Twenty-nine patients with MSA-P and 28 healthy controls underwent [18F]FDG brain PET scan. The [18F]FDG brain PET images were semiquantitatively analyzed on the basis of a template in standard space. The regional glucose metabolism of the cerebral cor

SUBMITTER: Kim HW 

PROVIDER: S-EPMC5234778 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature