The Yin and Yang of Memory Consolidation: Hippocampal and Neocortical.

ABSTRACT: While hippocampal and cortical mechanisms of memory consolidation have long been studied, their interaction is poorly understood. We sought to investigate potential interactions with respect to trace dominance, strengthening, and interference associated with postencoding novelty or sleep. A learning procedure was scheduled in a watermaze that placed the impact of novelty and sleep in opposition. Distinct behavioural manipulations-context preexposure or interference during memory retrieval-differentially affected trace dominance and trace survival, respectively. Analysis of immediate early gene expression revealed parallel up-regulation in the hippocampus and cortex, sustained in the hippocampus in association with novelty but in the cortex in association with sleep. These findings shed lig

SUBMITTER: Genzel L 

PROVIDER: S-EPMC5234779 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature