Stress and reward processing in bipolar disorder: a functional magnetic resonance imaging study.

ABSTRACT:

Objectives

A link between negative life stress and the onset of mood episodes in bipolar disorder (BD) has been established, but processes underlying such a link remain unclear. Growing evidence suggests that stress can negatively affect reward processing and related neurobiological substrates, indicating that a dysregulated reward system may provide a partial explanation. The aim of this study was to test the impact of stress on reward-related neural functioning in BD.

Methods

Thirteen euthymic or mildly depressed individuals with BD and 15 controls performed a Monetary Incentive Delay (MID) task while undergoing functional magnetic resonance imaging during no-stress and stress (negative psychosocial stressor involving poor performance feedback and threat of monetary deduct

SUBMITTER: Berghorst LH 

PROVIDER: S-EPMC5234857 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature