Progressive Decrease of Mitochondrial Motility during Maturation of Cortical Axons In Vitro and In Vivo.

ABSTRACT: The importance of mitochondria for neuronal function is evident by the large number of neurodegenerative diseases that have been associated with a disruption of mitochondrial function or transport (reviewed in [1, 2]). Mitochondria are essential for proper biological function as a result of their ability to produce ATP through oxidative phosphorylation, buffer cytoplasmic calcium, regulate lipid biosynthesis, and trigger apoptosis (reviewed in [2]). Efficient transport of mitochondria is thought to be particularly important in neurons in light of their compartmentalization, length of axonal processes, and high-energy requirements (reviewed in [3]). However, the majority of these results were obtained using short-term, in vitro neuronal culture models, and very little is currently known abo

SUBMITTER: Lewis TL 

PROVIDER: S-EPMC5235338 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature