Multi-variant study of obesity risk genes in African Americans: The Jackson Heart Study.

ABSTRACT:

Objective

Genome-wide association study (GWAS) has been successful in identifying obesity risk genes by single-variant association analysis. For this study, we designed steps of analysis strategy and aimed to identify multi-variant effects on obesity risk among candidate genes.

Methods

Our analyses were focused on 2137 African American participants with body mass index measured in the Jackson Heart Study and 657 common single nucleotide polymorphisms (SNPs) genotyped at 8 GWAS-identified obesity risk genes.

Results

Single-variant association test showed that no SNPs reached significance after multiple testing adjustment. The following gene-gene interaction analysis, which was focused on SNPs with unadjusted p-value<0.10, identified 6 significant multi-variant associat

SUBMITTER: Liu S 

PROVIDER: S-EPMC5235348 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature