Microfluidic Biopsy Trapping Device for the Real-Time Monitoring of Tumor Microenvironment.

ABSTRACT: The tumor microenvironment is composed of cellular and stromal components such as tumor cells, mesenchymal cells, immune cells, cancer associated fibroblasts and the supporting extracellular matrix. The tumor microenvironment provides crucial support for growth and progression of tumor cells and affects tumor response to therapeutic interventions. To better understand tumor biology and to develop effective cancer therapeutic agents it is important to develop preclinical platforms that can faithfully recapitulate the tumor microenvironment and the complex interaction between the tumor and its surrounding stromal elements. Drug studies performed in vitro with conventional two-dimensional cancer cell line models do not optimally represent clinical drug response as they lack true tumor heterog

SUBMITTER: Holton AB 

PROVIDER: S-EPMC5235371 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature