Association of inflammatory, lipid and mineral markers with cardiac calcification in older adults.

ABSTRACT:

Objective

Calcification of the aortic valve and adjacent structures involves inflammatory, lipid and mineral metabolism pathways. We hypothesised that circulating biomarkers reflecting these pathways are associated with cardiac calcification in older adults.

Methods

We investigated the associations of various biomarkers with valvular and annular calcification in the Cardiovascular Health Study. Of the 5888 participants, up to 3585 were eligible after exclusions for missing biomarker, covariate or echocardiographic data. We evaluated analytes reflecting lipid (lipoprotein (Lp) (a), Lp-associated phospholipase A₂ (LpPLA₂) mass and activity), inflammatory (interleukin-6, soluble (s) CD14) and mineral metabolism (fetuin-A, fibroblast growth factor (FGF)-23)

SUBMITTER: Bortnick AE 

PROVIDER: S-EPMC5235996 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature