Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage.

ABSTRACT:

Background and purpose

Hematoma clearance occurs in the days after intracerebral hemorrhage (ICH) and has not been well studied. In the current study, we examined changes in the hematoma in a piglet ICH model. The effect of deferoxamine on hematoma was also examined.

Methods

The ICH model was induced by an injection of autologous blood into the right frontal lobe of piglets. First, a natural time course of hematoma changes ≤7 days was determined. Second, the effect of deferoxamine on hematoma changes was examined. Hemoglobin and membrane attack complex levels in the hematoma were examined by enzyme-linked immunosorbent assay. Immunohistochemistry and Western blotting were used to examine CD47 (a regulator of erythrophagocytosis), CD163 (a hemoglobin scavenger receptor), and

SUBMITTER: Cao S 

PROVIDER: S-EPMC5237112 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature