Toxoplasmosis-associated IRIS involving the CNS: a case report with longitudinal analysis of T cell subsets.

ABSTRACT:

Background

HIV-infected patients may present an unforeseen clinical worsening after initiating antiretroviral therapy known as immune reconstitution inflammatory syndrome (IRIS). This syndrome is characterized by a heightened inflammatory response toward infectious or non-infectious triggers, and it may affect different organs. Diagnosis of IRIS involving the central nervous system (CNS-IRIS) is challenging due to heterogeneous manifestations, absence of biomarkers to identify this condition, risk of long-term sequelae and high mortality. Hence, a deeper knowledge of CNS-IRIS pathogenesis is needed.

Case presentation

A 37-year-old man was diagnosed with AIDS and cerebral toxoplasmosis. Anti-toxoplasma treatment was initiated immediately, followed by active antiretroviral the

SUBMITTER: Rb-Silva R 

PROVIDER: S-EPMC5237164 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature