Comprehensive CircRNA expression profile and selection of key CircRNAs during priming phase of rat liver regeneration.

ABSTRACT:

Background

Rat liver regeneration (LR) proceeds along a process of highly organized and ordered tissue growth in response to the loss or injury of liver tissue, during which many physiological processes may play important roles. The molecular mechanism of hepatocyte proliferation, energy metabolism and substance metabolism during rat LR had been elucidated. Further, the correlation of circular RNA (circRNA) abundance with proliferation has recently been clarified. However, the regulatory capacity of circRNA in rat LR remains a fascinating topic.

Results

To investigate the regulatory mechanism of circRNA during priming phase of rat LR, high-throughput RNA sequencing technology was performed to unbiasedly profile the expression of circRNA during priming phase of rat LR. Gene o

SUBMITTER: Li L 

PROVIDER: S-EPMC5237265 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature