Evolution of the angiopoietin-like gene family in teleosts and their role in skin regeneration.

ABSTRACT:

Background

The skin in vertebrates is a protective barrier and damage is rapidly repaired to re-establish barrier function and maintain internal homeostasis. The angiopoietin-like (ANGPTL) proteins are a family of eight secreted glycoproteins with an important role in skin repair and angiogenesis in humans. In other vertebrates their existence and role in skin remains largely unstudied. The present study characterizes for the first time the homologues of human ANGPTLs in fish and identifies the candidates that share a conserved role in skin repair using a regenerating teleost skin model over a 4-day healing period.

Results

Homologues of human ANGPTL1-7 were identified in fish, although ANGPTL8 was absent and a totally new family member designated angptl9 was identified in fi

SUBMITTER: Costa RA 

PROVIDER: S-EPMC5237311 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature