HIV Infection Is Independently Associated with Increased CT Scan Lung Density.

ABSTRACT:

Rationale and objectives

Noninfectious pulmonary complications are common among HIV-infected individuals and may be detected early by quantitative computed tomography (CT) scanning. The association of HIV disease markers with CT lung density measurement remains poorly understood.

Materials and methods

One hundred twenty-five participants free of spirometry-defined lung disease were recruited from a longitudinal cohort study of HIV-infected and HIV-uninfected individuals to undergo standardized CT scan of the chest. Parenchymal density for the entire lung volume was calculated using computerized software. Qualitative assessment of CT scans was conducted by two radiologists masked to HIV status. Linear regression models were developed to determine the independent association o

SUBMITTER: Drummond MB 

PROVIDER: S-EPMC5237394 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature