The interleukin-6-hepcidin-hemoglobin circuit in systemic lupus erythematosus flares.

ABSTRACT: Objective Hepcidin regulates iron availability and may be responsible for the anemia of chronic disease because it is induced by interleukin-6. This study investigated the IL-6-hepcidin-hemoglobin axis in patients with lupus. Methods IL-6 and hepcidin were measured in serial serum samples collected before, during and after lupus flares by specific ELISAs. Results During renal and non-renal SLE flare cycles IL-6 did not predict hepcidin and hepcidin did not predict hemoglobin. When lupus nephritis patients were in remission, IL-6 and hepcidin were correlated, but hepcidin and hemoglobin were not. Conclusion Hepcidin does not contribute significantly to anemia during active lupus.

SUBMITTER: Indrakanti DL 

PROVIDER: S-EPMC5237426 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature