Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine.

ABSTRACT: Elevation of intraocular pressure (IOP) due to therapeutic use of glucocorticoids is called steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma (SIG). Glucocorticoids initiate signaling cascades ultimately affecting expression of hundreds of genes; this provides the potential for a highly personalized pharmacological response. Studies attempting to define genetic risk factors were undertaken early in the history of glucocorticoid use, however scientific tools available at that time were limited and progress stalled. In contrast, significant advances were made over the ensuing years in defining disease pathophysiology. As the genomics age emerged, it appeared the time was right to renew investigation into genetics. Pharmacogenomics is an unbiased discovery

SUBMITTER: Fini ME 

PROVIDER: S-EPMC5237612 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature