Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.

ABSTRACT: Herein we report the discovery and hit-to-lead optimization of a series of spirocyclic piperidine aldosterone synthase (CYP11B2) inhibitors. Compounds from this series display potent CYP11B2 inhibition, good selectivity versus related CYP enzymes, and lead-like physical and pharmacokinetic properties.

SUBMITTER: Petrilli WL 

PROVIDER: S-EPMC5238464 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature