Novel Potentiators for Vancomycin in the Treatment of Biofilm-Related MRSA Infections via a Mix and Match Approach.

ABSTRACT: A library of 52 hamamelitannin analogues was synthesized and investigated for its ability to potentiate the effect of vancomycin toward Staphylococcus aureus biofilms. Several compounds were found to effectively increase the susceptibility of staphylococcal biofilms toward this glycopeptide. The most active analogue identified in this study showed an EC₅₀ value of 0.26 μM.

SUBMITTER: Vermote A 

PROVIDER: S-EPMC5238489 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature