Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP.

ABSTRACT: Activation of resident and infiltrating immune cells is a central event in training adaptation and other contexts of skeletal muscle repair and regeneration. A precise orchestration of inflammatory events in muscle fibers and immune cells is required after recurrent contraction-relaxation cycles. However, the mechanistic aspects of this important regulation remain largely unknown. We now demonstrate that besides a dominant role in controlling cellular metabolism, the peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) also has a profound effect on cytokine expression in muscle tissue. Muscle PGC-1α expression results in activation of tissue-resident macrophages, at least in part mediated by PGC-1α-dependent B-type natriuretic peptide (BNP) production and secretion. Positi

SUBMITTER: Furrer R 

PROVIDER: S-EPMC5238507 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature