Versatile synthesis of end-reactive polyrotaxanes applicable to fabrication of supramolecular biomaterials.

ABSTRACT: Cyclodextrin (CD)-threaded polyrotaxanes (PRXs) with reactive functional groups at the terminals of the axle polymers are attractive candidates for the design of supramolecular materials. Herein, we describe a novel and simple synthetic method for end-reactive PRXs using bis(2-amino-3-phenylpropyl) poly(ethylene glycol) (PEG-Ph-NH₂) as an axle polymer and commercially available 4-substituted benzoic acids as capping reagents. The terminal 2-amino-3-phenylpropyl groups of PEG-Ph-NH₂ block the dethreading of the α-CDs after capping with 4-substituted benzoic acids. By this method, two series of azide group-terminated polyrotaxanes (benzylazide: PRX-Bn-N_3, phenylazide: PRX-Ph-N_3,) were synthesized for functionalization via click reactions. The PRX-B

SUBMITTER: Tamura A 

PROVIDER: S-EPMC5238546 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature