Sydnone C-4 heteroarylation with an indolizine ring via Chichibabin indolizine synthesis.

ABSTRACT: The synthesis of sydnones heteroarylated at C-4 with an indolizine was achieved by Chichibabin (Tschitschibabin) indolizine synthesis starting from the corresponding sydnone-N-pyridinium bromides. The latter compounds were also transformed to sydnone-indolizines connected through a keto group at the C-4 position by refluxing them in 1,2-epoxybutane with an activated alkyne. The structures of the new compounds were assigned by FTIR, NMR spectroscopy and X-ray analysis.

SUBMITTER: Albota F 

PROVIDER: S-EPMC5238577 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature