A direct method for the N-tetraalkylation of azamacrocycles.

ABSTRACT: An efficient protocol for the direct synthesis of N-tetraalkylated derivatives of the azamacrocycles cyclam and cyclen has been developed, using a partially miscible aqueous-organic solvent system with propargyl bromide, benzyl bromide, and related halides. The method works most effectively when the reaction mixture is shaken, not stirred. A crystal structure of the N-tetrapropargyl cyclam derivative 1,4,8,11-tetra(prop-2-yn-1-yl)-1,4,8,11-tetraazacyclotetradecane diperchlorate is reported.

SUBMITTER: Counsell AJ 

PROVIDER: S-EPMC5238601 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature