Antitumor magnetic hyperthermia induced by RGD-functionalized Fe₃O₄ nanoparticles, in an experimental model of colorectal liver metastases.

ABSTRACT: This work reports important advances in the study of magnetic nanoparticles (MNPs) related to their application in different research fields such as magnetic hyperthermia. Nanotherapy based on targeted nanoparticles could become an attractive alternative to conventional oncologic treatments as it allows a local heating in tumoral surroundings without damage to healthy tissue. RGD-peptide-conjugated MNPs have been designed to specifically target α_Vβ₃ receptor-expressing cancer cells, being bound the RGD peptides by "click chemistry" due to its selectivity and applicability. The thermal decomposition of iron metallo-organic precursors yield homogeneous Fe₃O₄ nanoparticles that have been properly functionalized with RGD peptides, and the preparation

SUBMITTER: Arriortua OK 

PROVIDER: S-EPMC5238624 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature