Differential changes in hippocampal CaMKII and GluA1 activity after memory training involving different levels of adaptive forgetting.

ABSTRACT: Phosphorylation of CaMKII and AMPA receptor GluA1 subunit has been shown to play a major role in hippocampal-dependent long-term/reference memory (RM) and in the expression of long-term synaptic potentiation (LTP). In contrast, it has been proposed that dephosphorylation of these proteins could be involved in the opposite phenomenon of hippocampal long-term synaptic depression (LTD) and in adaptive forgetting. Adaptive forgetting allows interfering old memories to be forgotten to give new ones the opportunity to be stored in memory, and in particular in short-term/working memory (WM) that was shown to be very sensitive to proactive interference. To determine the role of CaMKII and GluA1 in adaptive forgetting, we adopted a comparative approach to assess the relative quantity and phosphoryl

SUBMITTER: Fraize N 

PROVIDER: S-EPMC5238719 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature