DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.

ABSTRACT: Disruption of apical-basal polarity is implicated in developmental disorders and cancer; however, the mechanisms connecting cell polarity proteins with intracellular signaling pathways are largely unknown. We determined previously that membrane-associated guanylate kinase (MAGUK) protein discs large homolog 5 (DLG5) functions in cell polarity and regulates cellular proliferation and differentiation via undefined mechanisms. We report here that DLG5 functions as an evolutionarily conserved scaffold and negative regulator of Hippo signaling, which controls organ size through the modulation of cell proliferation and differentiation. Affinity purification/mass spectrometry revealed a critical role of DLG5 in the formation of protein assemblies containing core Hippo kinases mammalian ste20 homo

SUBMITTER: Kwan J 

PROVIDER: S-EPMC5238729 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature