In Vivo Long-Term Biodistribution, Excretion, and Toxicology of PEGylated Transition-Metal Dichalcogenides MS₂ (M = Mo, W, Ti) Nanosheets.

ABSTRACT: With unique 2D structures and intriguing physicochemical properties, various types of transition metal dichalcogenides (TMDCs) have attracted much attention in many fields including nanomedicine. Hence, it is of great importance to carefully study the in vivo biodistribution, excretion, and toxicology profiles of different TMDCs, and hopefully to identify the most promising type of TMDCs with low toxicity and fast excretion for further biomedical applications. Herein, the in vivo behaviors of three representative TMDCs including molybdenum dichalcogenides (MoS₂), tungsten dichalcogenides (WS₂), and titanium dichalcogenides (TiS₂) nanosheets are systematically investigated. Without showing significant in vitro cytotoxicity, all the three types of polyethylen

SUBMITTER: Hao J 

PROVIDER: S-EPMC5238746 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature