Identification of urinary exosomal noncoding RNAs as novel biomarkers in chronic kidney disease.

ABSTRACT: In chronic kidney disease (CKD), the decline in the glomerular filtration rate is associated with increased morbidity and mortality and thus poses a major challenge for healthcare systems. While the contribution of tissue-derived miRNAs and mRNAs to CKD progression has been extensively studied, little is known about the role of urinary exosomes and their association with CKD. Exosomes are small, membrane-derived endocytic vesicles that contribute to cell-to-cell communication and are present in various body fluids, such as blood or urine. Next-generation sequencing approaches have revealed that exosomes are enriched in noncoding RNAs and thus exhibit great potential for sensitive nucleic acid biomarkers in various human diseases. Therefore, in this study we aimed to identify urinary exosom

SUBMITTER: Khurana R 

PROVIDER: S-EPMC5238789 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature