RiboCAT: a new capillary electrophoresis data analysis tool for nucleic acid probing.

ABSTRACT: Chemical and enzymatic probing of RNA secondary structure and RNA/protein interactions provides the basis for understanding the functions of structured RNAs. However, the ability to rapidly perform such experiments using capillary electrophoresis has been hampered by relatively labor-intensive data analysis software. While these computationally robust programs have been shown to calculate residue-specific reactivities to a high degree of accuracy, they often require time-consuming manual intervention and lack the ability to be easily modified by users. To alleviate these issues, RiboCAT (Ribonucleic acid capillary-electrophoresis analysis tool) was developed as a user-friendly, Microsoft Excel-based tool that reduces the need for manual intervention, thereby significantly shortening the ti

SUBMITTER: Cantara WA 

PROVIDER: S-EPMC5238798 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature