Preparation, cytotoxicity, and in vivo antitumor efficacy of ¹¹¹In-labeled modular nanotransporters.

ABSTRACT:

Purpose

Modular nanotransporters (MNTs) are a polyfunctional platform designed to achieve receptor-specific delivery of short-range therapeutics into the cell nucleus by receptor-mediated endocytosis, endosome escape, and targeted nuclear transport. This study evaluated the potential utility of the MNT platform in tandem with Auger electron emitting ¹¹¹In for cancer therapy.

Methods

Three MNTs developed to target either melanocortin receptor-1 (MC1R), folate receptor (FR), or epidermal growth factor receptor (EGFR) that are overexpressed on cancer cells were modified with p-SCN-Bn-NOTA and then labeled with ¹¹¹In in high specific activity. Cytotoxicity of the ¹¹¹In-labeled MNTs was evaluated on cancer cell lines bearing the appropriate recept

SUBMITTER: Slastnikova TA 

PROVIDER: S-EPMC5238804 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature