Interactions between single nucleotide polymorphism of SERPINA1 gene and smoking in association with COPD: a case-control study.

ABSTRACT:

Background

SERPINA1 gene has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), while smoking is a known risk factor for COPD. Little is known on the effect of SERPINA1 gene and its interaction with smoking in the Chinese population. In this study, the effect of SERPINA1 gene polymorphisms on COPD risk and its interaction with smoking status has been investigated.

Method

A total of 120 COPD patients and 481 healthy controls were recruited at The Armed Police Corps Hospital. Data on demographic variables, smoking status, history of occupational dust exposure, and allergies were collected. Genotyping for single nucleotide polymorphism's (SNP) rs1243160, rs2854254, and rs8004738 was performed in all participants.

Results

SUBMITTER: Deng X 

PROVIDER: S-EPMC5238810 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature