A toll-like receptor 9 (rs352140) variant is associated with placental inflammation in newborn infants.

ABSTRACT:

Objective

Chorioamnionitis contributes to premature birth and associated postnatal morbidity. The genetic basis of altered immune responses underlying placental inflammation (PI) remains understudied. The aim of this study was to evaluate the relationship among TLR signaling pathway polymorphisms and different patterns of PI.

Methods

Prospective cohort study in infants involving cord blood collection and placental examination for PI. One hundred and fifty-nine infants enrolled in study out of which 28 were term (eight with PI) and 131 preterm (47 with PI). DNA from blood was genotyped for SNPs in TLR2, 4, 5, 9, NFKBI, NFKBIA, TIRAP, and IRAK1 genes using multiplexed single base extension assay.

Results

While there were no differences in BW, GA, gender, race, and SPL a

SUBMITTER: Karody V 

PROVIDER: S-EPMC5238957 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature