Within-Individual Variability: An Index for Subtle Change in Neurocognition in Mild Cognitive Impairment.

ABSTRACT:

Background

The transition from mild cognitive impairment (MCI) to Alzheimer's disease is characterized by a decline in cognitive performance in many domains. Cognitive performance profiles in MCI are heterogeneous, however, and additional insights into markers of incipient dementia are needed. Typically, studies focus on average or mean performance, but ignore consistency of performance across domains. WIV (within-individual variability) provides an index of this consistency and is a potential marker of cognitive decline.

Objective

To use neurocognitive data from the Alzheimer's Disease Neuroimaging Initiative cohort to measure neurocognitive variability.

Methods

The utility of WIV was measured, in addition to global neurocognitive performance (GNP), for identifying A

SUBMITTER: Roalf DR 

PROVIDER: S-EPMC5238959 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature