Prognostic value and their clinical implication of 89-gene signature in glioma.

ABSTRACT: Gliomas are the most common and aggressive primary tumors in adults. The current approaches, such as histological classification and molecular genetics, have limitation in prediction of individual therapeutic outcomes due to heterogeneity within the tumor groups. Recent studies have proposed several gene signatures to predict glioma's prognosis. However, most of the gene expression profiling studies have been performed on relatively small number of patients and combined probes from diverse microarray chips. Here, we identified prognostic 89 common genes from diverse microarray chips. The 89-gene signature classified patients into good and bad prognostic groups which differed in the overall survival significantly, reflecting the biological characteristics and heterogeneity. The robustness a

SUBMITTER: Shahid M 

PROVIDER: S-EPMC5239472 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature