Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism.

ABSTRACT: Metabolomics, an essential technique in precision medicine, contributes to the molecular fingerprinting of tumours, further helping to understand their pathogenesis. In this work, using a LC-ESI-QTOF-MS/MS platform, we demonstrated the existence of a specific metabolomic signature which could define endometrioid endometrial carcinoma (EEC), arising the endocannabinoid system as a potential pathway involved in EC pathogenesis. Metabolomics could also shed light in the processes involved in myometrial invasion, proposing new targets for possible therapeutic intervention. Consequently, we also described a different metabolomic profile in surface endometrioid carcinoma and myometrial invasive front. We validated pathways disclosed by metabolomics by immunohistochemistry. Specifically, endocann

SUBMITTER: Jove M 

PROVIDER: S-EPMC5239558 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature