Potential specific immunological indicators for stroke associated infection are partly modulated by sympathetic pathway activation.

ABSTRACT:

Background

Evidence has led to the consideration of immunodepression after stroke as an important contributor to stroke associated infection (SAI). However, so far no specific immunological indicator has been identified for SAI, and the underlying mechanism remains poorly understood.

Results

SAI patients had significantly higher IL-6 and IL-10 levels and lower HLA-DR levels than no-infection patients within 48h after stroke onset. NA significantly increased IL-10 levels, reduced HLA-DR expression, and decreased IL-6 expression by increasing β-arrestin2 expression which reduced the activation of the NF-κB pathway. Propranolol reversed this effect of NA by reducing β-arrestin2 expression.

Materials and methods

A systematic search for eligible clinical studies was applie

SUBMITTER: Wang H 

PROVIDER: S-EPMC5239561 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature