Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis.

ABSTRACT:

Background

Prostate cancer (Pca) is a serious disease associated with considerable morbidity and mortality. As a causative factor, the Asp148Glu polymorphism has been identified in the apurinic/apyrimidinic endonuclease (APEX1) gene. However, the association among Asians is considered controversial.

Methods

Evidence for this association was obtained from the PubMed, Embase, HuGENet and Chinese National Knowledge Infrastructure (CNKI) databases. In the analysis, four models were applied. Associations between the APEX1 polymorphism and the invasiveness of Pca based on the Gleason score, prostate-specific antigen expression and clinical status were also evaluated.

Results

Seven articles were included in the analysis. Positive results were not only discovered in the poole

SUBMITTER: Chen Y 

PROVIDER: S-EPMC5239571 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature